The World Health Organization (WHO) has officially declared an end to the global hantavirus outbreak that was linked to a cruise ship, MV Hondius, which set sail from Argentina on April 1. The last individual who came into contact with the virus during the voyage completed their quarantine period and tested negative for the Andes strain of hantavirus, which typically circulates in Argentina and Chile. This marks the end of an outbreak that infected 13 people and resulted in three deaths. The ship sailed to remote islands in the South Atlantic Ocean, including Tristan da Cunha, before heading north to Tenerife in Spain’s Canary Islands. After cleaning and disinfection, the ship was cleared to set sail again on May 30. During the outbreak, more than 650 contacts were identified and followed up by health authorities in 33 countries and territories. The WHO will continue to work towards understanding the virus and its transmission patterns, as well as coordinating a study involving 21 countries to develop diagnostics, therapeutics, and vaccines for future outbreaks. Hantavirus is primarily spread through rodents, with humans contracting it through contact with rats, mice, their urine, droppings, and saliva. The Andes virus is the only known hantavirus strain that can also spread through close, prolonged human-to-human contact, causing symptoms such as fever, headache, muscle aches, nausea, abdominal pain, coughing, shortness of breath, and fluid accumulation in the lungs. As there are currently no approved vaccines or targeted antiviral treatments for hantavirus infection, care primarily remains supportive.